The group of Dr. Pavla Perlíková (https://uoch.vscht.cz/research-groups/perlikova-en) at the Department of Organic Chemistry of the University of Chemistry and Technology (UCT) in Prague is looking for PhD students in organic/medicinal chemistry. Two PhD topics are announced for 2024/2025.
Synthesis of inhibitors of the Arp2/3 complex
Migrastatics represent a new concept of drugs with a great potential to improve the outcome of the current cancer treatment strategies by inhibiting metastatic behavior of cancer cells. Our goal is to use rational design to develop new inhibitors of actin polymerization by targeting the Arp2/3 complex (actin-polymerization nucleator). The project includes a synthesis of hits from virtual screening and its optimization and structure-activity relationship studies. The position is funded by a prestigious Junior STAR grant by the Czech Science Foundation.
Synthesis of inhibitors of transcription factors involved in metabolic diseases
Transcription factors play an important role in the regulation of gene expression. Deregulation of key protein synthesis leads to a variety of metabolic diseases. The aim of this work is to use rational drug design to prepare suitable inhibitors of selected transcription factors and to further investigate the structure-activity relationship. The position is funded by the Excellent Research Call OP JAK project.
- Study at the largest higher education institution devoted to education and research in the field of chemistry in Central Europe
- Work in a small team and friendly environment
- 36-month contract (salary + scholarship)
Low cost of living in tolerant, progressive and secure country with rich cultural and natural heritage
Study in the heart of Europe with convenient transport connections to the whole world
We are looking for
- Highly motivated candidates with background in synthetic organic chemistry
- MSc. degree in organic/medicinal chemistry (or soon-to-be graduate)
- Pro-active, flexible and responsible students
- Excellent command of English (oral and written)
- Applications will be reviewed on a rolling basis
- Expected start: September 2024
How to apply
The University of Chemistry and Technology Prague (UCT Prague) is one of the largest Central European educational and research centers performing cutting-edge research focused on chemistry, chemical and biochemical technologies, material and chemical engineering, food science, environmental studies and related disciplines. UCT Prague collaborates with more than 100 academic institutions worldwide, is active in industrial R&D and technology transfer.
Some of UCT Prague programs are unique to the Czech Republic and essential to the country’s future. UCT ranked as the 3rd best Czech university in the Nature Index 2020 Rankings and 2nd in the QS World University Rankings 2021 and 2022. The small student-to-academic instructor ratio, allowing for individual support and inherent involvement of students in the research process, earned UCT 35th place in the world and 4th in Czechia in this aspect of rankings (2024 edition).