We are seeking a talented and motivated candidate to join a research team headed by Dr. Lukáš Čajánek at Masaryk University, Faculty of Medicine (http://www2.med.muni.cz/histology/lukas-cajanek/
) The selected candidate will have an opportunity to pursue molecular mechanisms controlling formation of primary cilia and functional aspects related to their defects in human cells
. The primary cilium (PC) is an antenna-like structure present on the surface of cells. Whilst it was originally described as a vestigial organelle, recent years have indisputably proven its status as a seminal structure for sensing various extracellular stimuli. PCs govern many important aspects of embryonic development as well as tissue homeostasis in adulthood. Consequently, deregulation of PC assembly, maintenance or function is linked to numerous human diseases, collectively termed ciliopathies. The successful candidate will have access to state-of-the-art methodology and instrumentation (proteomics, gene editing, lentiviral transduction, live imaging and high-resolution microscopy, etc.) The host lab is currently supported by funding from Czech Science Foundation (GACR) and Swiss National Science Foundation (SNSF). Relevant literature
: Bernatik O, Pejskova P, Vyslouzil D, Hanakova K, Zdrahal Z, Cajanek L. Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2. bioRxiv
676338; doi: https://doi.org/10.1101/676338. Bryja V, Červenka I, Čajánek L. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Crit Rev Biochem Mol Biol
. 2017. Čajánek L, Nigg EA. Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. PNAS
, 2014. Bhogaraju S, Čajánek L, et al. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science
, 2013. Requirements and qualifications
- The candidate obtained within the the past 7 years a Ph.D. degree in cell biology, molecular biology, or similar fields.
- The candidate is expected to have strong research experience and a solid publication record in well recognized scientific journals, including at least one first-author publication.
The candidate has to prove the interest and motivation to tackle scientific challenges, independent planning of experiments to explore given hypotheses and technical skills to carry on the experimental work. The candidate is expected to be skilled in mammalian cell culture, broad spectrum of molecular-biology techniques, and advanced microscopy. The candidate should have the ability to prioritize tasks and responsibilities and independently solve project-related issues. Additional requirements include good communication skills, excellent documentation skills and the ability to work both independently and as a part of an international team. We offer
Anticipated start date:
- To become a part of enthusiastic scientific team working on a challenging projects
- To publish results in recognized scientific journals
- Full support of the administrative and project offices
- Stimulating and diverse work environment
- Support of the Welcome office for the succesfull applicant and his/her family
- Competitive salary (up to two years contract)
The position is available from March/April 2020 or upon agreement but no later than by 30th November 2020. Applications and selection process
for applications is February 29, 2020
. A review of applications will run continuously as received. The short listed candidates will be invited for an interview.