PhD Position in Structural Biology of Host-Pathogen Interactions

Job description

A position for a talented and motivated PhD student is open in Zoll lab at the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague. The group focuses on understanding the structural basis of interactions between surface proteins of parasites and viruses with human host factors to foster the development of novel therapeutic strategies against neglected diseases.

The successful candidate will be using an integrated structural biology approach including single particle cryo-EM, X-ray crystallography as well as small angle X-ray scattering together with a wide range of biophysical techniques for characterisation of protein-protein interactions (e.g. SPR, ITC, MALS, MST). The position will include practical training in a protein biochemistry lab as well training in processing of structural data using Linux work stations.

The lab is well-funded and supported by a multidisciplinary network of international collaborators thus providing excellent opportunities to receive additional training in foreign host institutions.


We are looking for candidates with an M.Sc. in biology, biochemistry or a related discipline and a strong interest in structural biology. The successful candidate must be willing to work as part of a team and have the motivation and commitment to design experiments and interpret results independently. Experience in structural biology techniques is not required but familiarity with recombinant protein expression and protein purification will be a plus. Good oral and written communication skills in English are a prerequisite.

We offer

  • 5 weeks of vacation plus 3 sick days
  • Health insurance and full benefits package
  • Contribution to sports/culture/leisure time
  • Meal subsidy by means of meal voucher lump sum
  • Financial support for mothers with young children

How to apply?

Please send a short motivation statement (max. 500 words), a copy of your research thesis and M.Sc. certificate (if already available), a copy of your CV and contact information for two references to Tato e-mailová adresa je chráněna před spamboty. Pro její zobrazení musíte mít povolen Javascript.

Feel free to contact Sebastian for informal enquiries.

Dr Sebastian Zoll
Junior Group Leader


The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences / IOCB Prague is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.